Cosmetic Ingredient

SH-Polypeptide-123

INCI: SH-POLYPEPTIDE-123
CAS 1375784-79-4
sh-Polypeptide-123 is a single chain recombinant human peptide, produced by fermentation in Pichia pastoris. The starting gene is synthesized to be similar to the human gene which codes for Collagen Alpha-1 (III) Chain used as such or adapted to the production host. It contains a maximum of 1466 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of all or part of the 20 standard amino acids.
Generally Safe
This ingredient has a good safety profile based on available data.
Purpose

Function

Skin protecting; highly purified type III human-like collagen (collagen alpha-1(III) chain, up to 1466 amino acids)
Profile

Properties

Silicone
Silicone free
Malassezia
Safe
Fungal Acne
Safe
Details

Description

sh-Polypeptide-123 is a single chain recombinant human peptide, produced by fermentation in Pichia pastoris. The starting gene is synthesized to be similar to the human gene which codes for Collagen Alpha-1 (III) Chain used as such or adapted to the production host. It contains a maximum of 1466 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of all or part of the 20 standard amino acids.

Reference

Identifiers

CAS Number
1375784-79-4
INCI
SH-POLYPEPTIDE-123
Category
Cosmetic Ingredient
Updated
Apr 2, 2026