Active Compound

acetyl dipeptide-1

Neurotransmitter inhibitor dipeptide that stimulates nerve cells to release met-enkephalin, an endogenous opioid peptide. Results in muscle relaxation and reduced skin inflammation. Mechanism is distinct from SNARE complex inhibitors and postsynaptic receptor antagonists, enabling multi-pathway combination formulation strategies.
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Neurotransmitter inhibitor dipeptide that stimulates nerve cells to release met-enkephalin, an endogenous opioid peptide. Results in muscle relaxation and reduced skin inflammation. Mechanism is distinct from SNARE complex inhibitors and postsynaptic receptor antagonists, enabling multi-pathway combination formulation strategies.

Purpose

Function

Neurotransmitter inhibitor dipeptide that stimulates nerve cells to release met-enkephalin, an endogenous opioid peptide. Results in muscle relaxation and reduced skin inflammation. Mechanism is distinct from SNARE complex inhibitors and postsynaptic receptor antagonists, enabling multi-pathway combination formulation strategies.
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
GOOD
US
Permitted
Absorptionnegligible
Sensitizationnone
MoSadequate
ConcernLow
Verdict

Acetyl dipeptide-1 cetyl ester is a neurocosmetic active that modulates neuropeptide signaling to reduce sensory neuron firing, addressing reactive skin symptoms through CGRP and substance P pathway modulation without EU or US restrictions.

US Note

Permitted; no US concentration cap. Used in neurocosmetic formulations targeting reactive skin.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

Category
Active Compound
Updated
Apr 23, 2026

No registry identifiers available for this ingredient.