active

Zinc Pca

INCI: ZINC PCA
CAS 15454-75-8 EC 268-475-9 / 239-473-5
Proline, 5-oxo-, zinc salt
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Proline, 5-oxo-, zinc salt

Purpose

Function

Sebum regulator; antimicrobial; astringent; humectant (PCA moiety); keratinocyte-supporting trace mineral; cofactor for superoxide dismutase and matrix metalloproteinases; acne-control active
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
EU Max Concentration0.5–2%
Absorptionmoderate
Sensitizationlow
MoSadequate
NOAEL83 mg/kg
ConcernNone
Flags
sebum-regulatoracne-controlantimicrobialnmf-componenttrace-mineralkeratinocyte-support
Verdict

Excellent multifunctional active for oily, acne-prone, and combination skin that targets sebum regulation, provides mild antimicrobial action, and contributes to keratinocyte health via zinc bioavailability with no safety concerns at typical use concentrations.

US Note

No FDA restriction; used in OTC acne aids as zinc source; not subject to sunscreen monograph.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
15454-75-8
EC Number
268-475-9 / 239-473-5
INCI
ZINC PCA
Category
active
Updated
Apr 2, 2026