Tripeptide-29
INCI: TRIPEPTIDE-29
CAS 2239-67-0
Tripeptide-29 is the synthetic peptide consisting of glycine, proline and hydroxyproline
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
Tripeptide-29 is the synthetic peptide consisting of glycine, proline and hydroxyproline
Purpose
Function
Collagen-mimetic biomimetic peptide that replicates the Gly-Pro-Hyp (glycine-proline-hydroxyproline) tripeptide sequence — the fundamental repeating unit of the collagen triple helix. Provides direct structural reinforcement and stimulates collagen synthesis by presenting a native ECM sequence to fibroblasts. Mechanism differs from signal peptides: Tripeptide-29 mimics the structural building block rather than a matrikine fragment.
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
GOOD
US
Permitted
Absorptionnegligible
Sensitizationnone
MoSnot established
ConcernLow
Flags
biomimetic-peptidecollagen-mimeticgly-pro-hypstructural-reinforcement
Verdict
Tripeptide-29 is a collagen-mimetic peptide presenting the native Gly-Pro-Hyp collagen repeat directly to skin cells for structural reinforcement without regulatory restrictions in EU or US, though clinical substantiation remains limited.
US Note
No specific FDA restrictions. No pre-market approval required under MoCRA for cosmetic peptides.
Assessment
Ratings
Reference