Tretinoin (0
Description
Keratolytic; normalizes keratinization; accelerates cell turnover; stimulates fibroblast collagen production. Used for atrophic acne scar treatment, photoaging, acne.
Function
Properties
Regulatory Status
Tretinoin (all-trans retinoic acid, CAS 302-79-4) is a prescription-only pharmaceutical in both the US and EU, not a cosmetic ingredient. Documented 0.05% tretinoin improves atrophic acne scars via normalized keratinization and accelerated cell turnover. Included in the database as a benchmark reference for formulators comparing cosmetic retinoid actives. EU: Prohibited in cosmetics. US: Prescription-only drug. Contraindicated in pregnancy due to teratogenic risk. Avoid application to open wounds.
Prescription-only drug (Rx) in the US for acne and photoaging treatment. Not permitted in OTC cosmetics under FDA classification. Requires CDER approval as a new drug application. Used clinically at 0.025–0.1% for acne; 0.05% shown to improve atrophic acne scars.
Ratings
Identifiers
No registry identifiers available for this ingredient.