Tazarotene
INCI: TAZAROTENE
CAS 118292-40-3
3-Pyridinecarboxylic Acid, 6-[(3,4-Dihydro-4,4-Dimethyl-2H-1-Benzothiopyran-6-yl)Ethynyl]-, Ethyl Ester
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
3-Pyridinecarboxylic Acid, 6-[(3,4-Dihydro-4,4-Dimethyl-2H-1-Benzothiopyran-6-yl)Ethynyl]-, Ethyl Ester
Purpose
Function
skin-conditioning, anti-aging
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Restricted
Safety
MODERATE
US
Restricted
EU Max ConcentrationPrescription only
Absorptionhigh
Sensitizationhigh
MoSnot established
NOAEL0.05 mg/kg
ConcernHigh
Flags
rx-onlyteratogenhigh-irritationrar-selective
Verdict
Most potent prescription topical retinoid with RAR-beta/gamma selectivity; highest irritation and teratogenicity risk in retinoid class, reserved for treatment-resistant photoaging or acne under medical supervision.
US Note
Rx; 0.05-0.1%; most potent topical retinoid; highest irritation risk
Assessment
Ratings
Reference