SH-Oligopeptide-1 (1
Description
Cell-communicating polypeptide (~6.2 kDa); binds EGFR driving keratinocyte and fibroblast proliferation; attenuates pro-inflammatory cytokines IL-1, IL-8, and TNF-α in keratinocytes; wound re-epithelialization support; anti-aging active
Function
Properties
Regulatory Status
SH-Oligopeptide-1 (EGF); CAS 62253-63-8; ~6 kDa molecular weight. EU: permitted with responsible person safety assessment required. US: permitted for cosmetic claims only; therapeutic/drug claims trigger classification as drug. Limited systemic absorption due to high molecular weight restricting stratum corneum penetration. No allergic reactions or significant sensitization observed in clinical trials; genotoxicity and mutagenicity negative.
FDA distinguishes cosmetic vs drug based on intended use claims. Purely aesthetic claims (hydration, appearance) are permissible. Claims such as accelerates wound healing or promotes cell regeneration may trigger drug classification requiring CDER approval under 21 CFR. No GRASE classification (not a sunscreen active). No specific restrictions in 21 CFR for cosmetic use.
Ratings
Identifiers
No registry identifiers available for this ingredient.