Retinal
INCI: RETINAL
CAS 116-31-4 EC 204-135-8
2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-
Purpose
Function
Keratinocyte turnover accelerator; melanin dispersal agent; retinoid receptor activator via retinoic acid conversion; anti-aging
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
GOOD
US
Permitted
Absorptionlow
Sensitizationnone
MoSnot established
NOAEL3 mg/kg
ConcernLow
Flags
eu-unrestrictedsccs-excludedno-mos-calculatedreproductive-toxicant-1bno-cir-assessment
Verdict
Retinaldehyde is a vitamin A aldehyde explicitly excluded from EU Regulation 2024/996 Annex III concentration limits and SCCS safety assessments due to insufficient data, with no formal regulatory margin of safety established but demonstrated clinical efficacy at 0.05-0.1% with superior tolerance and no documented sensitization at cosmetic concentrations.
US Note
Permitted in cosmetics without concentration limits. No specific FDA restrictions apply. Not evaluated as a sunscreen active and not approved as an OTC active ingredient. No dedicated CIR safety assessment has been conducted; CIR has assessed retinol and retinyl palmitate but not retinaldehyde.
Assessment
Ratings
Reference