Phloretin
INCI: PHLORETIN
CAS 60-82-2 [^1_9] EC 200-488-7
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Dihydronaringenin; 4,2',4',6'-Tetrahydroxydihydrochalcone
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Dihydronaringenin; 4,2',4',6'-Tetrahydroxydihydrochalcone
Purpose
Function
Antioxidant, anti-sebum; enhances skin penetration of other actives
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
GOOD
US
Permitted
Absorptionhigh
Sensitizationlow
MoSadequate
NOAEL50 mg/kg
ConcernLow
Flags
endocrine_disruptor
Verdict
SDS classifies as irritant to skin and mucous membranes; acts as a penetration enhancer with potential formulation-level interactions; oxidatively unstable and requires antioxidant stabilization such as ferulic acid and vitamin C systems.
US Note
FDA permitted; CIR has not published a dedicated review; widely used in commercial products (e.g., SkinCeuticals)
Assessment
Ratings
Reference