Active Compound

Pantothenic Acid Polypeptide

Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function support
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function support

Purpose

Function

Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function support
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionlow
Sensitizationnone
MoSadequate
NOAEL200 mg/kg
ConcernNone
Verdict

Pantothenic acid is the active metabolite of panthenol in skin, with CIR-confirmed safety in cosmetics. Less commonly used directly due to superior skin penetration of panthenol, which enzymatically converts to this compound in situ. Suitable for hair and skin conditioning with excellent safety profile and no sensitization concerns.

US Note

CIR Expert Panel assessed in same 1987 review as panthenol and derivatives — concluded safe in cosmetics in present practices of use and concentration. Reaffirmed after 15-year review. Coenzyme A constituent; essential for epithelial function.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

Category
Active Compound
Updated
Apr 23, 2026

No registry identifiers available for this ingredient.