Palmitoyl Tripeptide-1
INCI: PALMITOYL TRIPEPTIDE-1
CAS 147732-56-7
L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-
Purpose
Function
Skin-conditioning agent; collagen-stimulating peptide
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
GOOD
US
Permitted
Absorptionhigh
Sensitizationlow
MoSadequate
ConcernLow
Flags
peptidematrikinecollagen-stimulatinganti-agingeye-areamatrixyl
Verdict
Palmitoyl Tripeptide-1 (Gly-His-Lys sequence; component of Matrixyl 3000) drives collagen and glycosaminoglycan synthesis via fibroblast stimulation. CIR Expert Panel confirms Tripeptide-1 and its fatty acyl derivatives safe as used in cosmetics. A 28-day clinical study on 32 volunteers showed significant reductions in wrinkle depth, volume, and number. Standalone formulations show retinoid-comparable activity without irritation. No EU or US regulatory restrictions.
US Note
CIR Expert Panel confirmed Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 are safe as used in cosmetics. Covered under CIR safety assessment for this ingredient class.
Assessment
Ratings
Reference