Active Compound

Palmitoyl Tetrapeptide-72 Amide

Palmitoyl Tetrapeptide-72 Amide is the product obtained by the reaction of palmitoyl chloride and Tetrapeptide-72 in which the C-terminus is an amide.
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Palmitoyl Tetrapeptide-72 Amide is the product obtained by the reaction of palmitoyl chloride and Tetrapeptide-72 in which the C-terminus is an amide.

Purpose

Function

Skin Conditioning
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
GOOD
US
Permitted
Absorptionhigh
Sensitizationlow
MoSadequate
ConcernLow
Verdict

Palmitoyl Tetrapeptide-7 is confirmed safe as used in cosmetics by CIR Expert Panel. The peptide decreases IL-6 secretion after UVB exposure and stimulates collagen synthesis; in clinical studies it demonstrated significant reductions in wrinkle depth, volume, and number with no regulatory restrictions.

US Note

Explicitly named in CIR safety assessment as safe as used in cosmetics. Covered under same CIR review as Tripeptide-1 and Hexapeptide-12 derivatives.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

Category
Active Compound
Updated
Apr 23, 2026

No registry identifiers available for this ingredient.