active

Palmitoyl Hexapeptide-12

INCI: PALMITOYL HEXAPEPTIDE-12
CAS 171263-26-6
Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-

Purpose

Function

Signal peptide with palmitoyl lipidation for enhanced stratum corneum penetration. Stimulates extracellular matrix components. Used at very low active concentrations in W/W cream formulations.
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
GOOD
US
Permitted
Absorptionlow
Sensitizationnone
MoSadequate
ConcernLow
Verdict

Palmitoyl Hexapeptide-12 is a lipidated signal peptide used at very low concentrations (0.0004% active) in W/W cream formulations with no regulatory restrictions in EU or US markets.

US Note

No specific FDA restrictions. No pre-market approval required under MoCRA.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
171263-26-6
INCI
PALMITOYL HEXAPEPTIDE-12
Category
active
Updated
Apr 2, 2026