Morinda Citrifolia Extract (10

Morinda Citrifolia Fruit Extract is permitted in the EU with no Annex restrictions and allowed under EU Cosmetics Regulation 1223/2009. In the US, it falls under the general cosmetic ingredient framework with no FDA-specific restrictions. In vivo dermal toxicity studies in rats showed no treatment-related effects up to 5,000 mg/kg acute and 2,000 mg/kg/day subacute dosing. Key safety gaps include lack of HRIPT, dermal penetration data, phototoxicity data, and MoS; scopoletin and anthraquinone content warrant additional screening.

No FDA-specific restriction on cosmetic use. Not classified as an OTC monographed active ingredient and has no GRAS/GRASE status for cosmetic application. No CIR final report or Safety Literature Review published. Falls under general botanical extract framework with no pre-market approval required.