Antioxidant

L-Valine

Essential branched-chain amino acid that inhibits lipid peroxidation and enhances the accessibility of fat-soluble reactive oxygen species (ROS) for scavenging. The hydrophobic branched-chain side chain of valine partitions into lipid-rich environments (sebum, membrane bilayers), enabling antioxidant protection in the lipid phase of the skin. Component of the free amino acid antioxidant pool.
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Essential branched-chain amino acid that inhibits lipid peroxidation and enhances the accessibility of fat-soluble reactive oxygen species (ROS) for scavenging. The hydrophobic branched-chain side chain of valine partitions into lipid-rich environments (sebum, membrane bilayers), enabling antioxidant protection in the lipid phase of the skin. Component of the free amino acid antioxidant pool.

Purpose

Function

Essential branched-chain amino acid that inhibits lipid peroxidation and enhances the accessibility of fat-soluble reactive oxygen species (ROS) for scavenging. The hydrophobic branched-chain side chain of valine partitions into lipid-rich environments (sebum, membrane bilayers), enabling antioxidant protection in the lipid phase of the skin. Component of the free amino acid antioxidant pool.
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionlow
Sensitizationnone
MoSnot established
NOAEL628 mg/kg
ConcernNone
Flags
gras-fdacir-approvedantioxidantlipid-peroxidation-inhibitorbranched-chainfda_food_additive
Verdict

L-Valine is a branched-chain amino acid whose hydrophobic side chain enables access to lipid-phase ROS, inhibiting lipid peroxidation. Classified as a fat-soluble ROS-accessible antioxidant in skin. GRAS and CIR-class safe with no restrictions.

US Note

FDA GRAS as direct food additive. CIR amino acid class assessed safe.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

Category
Antioxidant
Updated
Apr 23, 2026

No registry identifiers available for this ingredient.