active

Glycine

INCI: GLYCINE
CAS 56-40-6 EC 200-272-2
Glycine
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Glycine

Purpose

Function

Most abundant amino acid in collagen (every third residue in Gly-X-Y triplet). Improves visible signs of aging, enhances moisture retention, promotes collagen production, strengthens skin, and supports repair and regeneration.
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionnegligible
Sensitizationnone
MoSadequate
NOAEL2000 mg/kg
ConcernNone
Flags
eu_children_restrictedepa_safer_alternativefda_food_additivejecfa_safe
Verdict

Glycine is structurally essential for collagen stability and a well-tolerated cosmetic active with CIR-assessed safety and confirmed GRAS status. No restrictions or safety concerns at cosmetic use levels.

US Note

Assessed as safe by CIR Expert Panel. GRAS as a direct food additive.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
56-40-6
EC Number
200-272-2
INCI
GLYCINE
Category
active
Updated
Apr 2, 2026