active

Copper Tripeptide-1

INCI: COPPER TRIPEPTIDE-1
CAS 49557-75-7
Copper Tripeptide-1 is a copper complex of Tripeptide-1
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Copper Tripeptide-1 is a copper complex of Tripeptide-1

Purpose

Function

GHK-Cu: glycine-histidine-lysine copper complex. Tissue-remodelling tripeptide with copper-dependent activation of fibroblast collagen types I/III and elastin synthesis, glycosaminoglycan production, superoxide dismutase (SOD) activation, wound-healing, and angiogenesis. Anti-aging, barrier repair, and anti-inflammatory activity.
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionmoderate
Sensitizationnone
MoSadequate
NOAEL50 mg/kg
ConcernNone
Flags
peptideanti-agingcollagen-synthesiscopper-complexinci-copper-tripeptide-1skinificationbody-care-expandingevidence-backedhigh-demand-2026
Verdict

GHK-Cu (Copper Tripeptide-1) is the best-characterised copper peptide complex with multi-mechanism anti-aging and repair activity supported by decades of academic and commercial research. Well-tolerated with excellent safety profile and unrestricted global regulatory status.

US Note

Permitted without restriction. INCI: Copper Tripeptide-1. MoCRA safety substantiation required.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
49557-75-7
INCI
COPPER TRIPEPTIDE-1
Category
active
Updated
Apr 2, 2026