Bispyrithione
INCI: BISPYRITHIONE
CAS 3696-28-4 EC 223-024-5
Bis(2-pyridine-N-oxide)Disulfide
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
Bis(2-pyridine-N-oxide)Disulfide
Purpose
Function
Antimicrobial, anti-dandruff agent, preservative (disulfide dimer of pyrithione)
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Banned
Safety
POOR
US
Permitted
Absorptionmoderate
Sensitizationmoderate
MoSadequate
ConcernHigh
Flags
preservative
Verdict
Bispyrithione is prohibited in EU cosmetics due to CMR 1B classification (reproductive toxicity); harmful if swallowed with aquatic toxicity concerns. In the US, use is limited to rinse-off anti-dandruff products only.
US Note
FDA: Zinc pyrithione is an approved OTC anti-dandruff active (21 CFR 358.710). Bispyrithione itself does not have separate FDA monograph status. CIR has not issued a standalone review.
Assessment
Ratings
Reference