Benzophenone-3
INCI: BENZOPHENONE-3
CAS 131-57-7 EC 205-031-5
2-Hydroxy-4-methoxybenzophenone
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
2-Hydroxy-4-methoxybenzophenone
Purpose
Function
UV Filter, Photostabilizer
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Restricted
Safety
MODERATE
US
Restricted
EU Max Concentration6% (sunscreen); 0.5% (non-UV-filter use)
Absorptionhigh
Sensitizationhigh
MoSadequate
NOAEL67.9 mg/kg
ConcernHigh
Flags
highly_sensitizinghigh_dermal_absorptionphotoallergenfda_not_graseeu_concentration_limitendocrine_concernavoid_skin_contact_formulasifra_fragranceeu_cosing_listed
Verdict
High dermal absorption with confirmed measurable systemic blood levels and bioaccumulation potential. Classified as highly sensitizing in nail formulation context with known photoallergen and contact allergen properties. EU-restricted with concentration limits; US-restricted for OTC sunscreen use. Avoid in nail formulations due to skin contact risk. Superior UV-filter alternatives available.
US Note
FDA 2019/2021 proposed rules: NOT GRASE pending additional safety data on systemic absorption and endocrine effects. Permitted in cosmetics generally; restriction applies to OTC sunscreen monograph specifically.
Assessment
Ratings
Reference