Atelocollagen
Description
Atelocollagen is the protein obtained when the telopeptides are enzymatically removed from collagen
Function
Properties
Regulatory Status
Animal-derived (typically bovine or porcine), raising BSE/TSE sourcing considerations - suppliers must provide certificates of origin from BSE-free countries; the telopeptide removal process significantly reduces immunogenicity compared to native collagen; acute oral toxicity LD50 > 20 mL/kg (rat). Produced by enzymatic (pepsin) treatment of native collagen to cleave the immunogenic telopeptide regions while preserving the triple-helix structure; lower molecular weight than intact collagen al...
Allowed - CIR (Cosmetic Ingredient Review) Expert Panel concluded it is safe in present practices of use and concentration as part of their assessment of skin and connective tissue-derived proteins