active

Ascorbyl (Vitamin C) Tetraisopalmitate

INCI: ASCORBYL TETRAISOPALMITATE
CAS 183476-82-6
Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires esterase-mediated hydrolysis to release ascorbic acid in skin; brightening active in anhydrous and oil-dominant formulations
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires esterase-mediated hydrolysis to release ascorbic acid in skin; brightening active in anhydrous and oil-dominant formulations

Purpose

Function

Oil-soluble vitamin C derivative; tyrosinase inhibitor; antioxidant; requires esterase-mediated hydrolysis to release ascorbic acid in skin; brightening active in anhydrous and oil-dominant formulations
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionhigh
Sensitizationmoderate
MoSadequate
ConcernModerate
Flags
cir-safe-as-used-2022eu-unrestrictedoil-solublesuperior-stabilitylipophilickorea-functional-cosmetic-whitening
Verdict

CIR safe as used (2022 update). Oil-soluble vitamin C derivative with superior stability shielded from oxidation. Lipophilic with limited systemic exposure. EU unrestricted and Korea MFDS approved functional cosmetic whitening active. Primary concern is allergic contact dermatitis cases; not recommended as primary brightening choice where alternatives with better safety records exist.

US Note

No FDA restriction. Allergic contact dermatitis cases published; use with caution. Not recommended as primary brightening active where alternatives with better safety records exist.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
183476-82-6
INCI
ASCORBYL TETRAISOPALMITATE
Category
active
Updated
Apr 2, 2026