Humectant

Arginine Pca

INCI: ARGININE PCA
CAS 56265-06-6 / 64855-91-0 EC 260-081-5 / 265-253-3
5-oxo-L-proline, compound with L-arginine (1:1)
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

5-oxo-L-proline, compound with L-arginine (1:1)

Purpose

Function

Humectant, Skin Conditioning, Hair Conditioning
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionlow
Sensitizationlow
MoSadequate
NOAEL3.131 mg/kg
ConcernNone
Verdict

Safe at cosmetic use levels; both arginine and PCA are endogenous NMF constituents.

US Note

CIR: Safe as used (covered under amino acid and PCA salt reviews)

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
56265-06-6 / 64855-91-0
EC Number
260-081-5 / 265-253-3
INCI
ARGININE PCA
Category
Humectant
Updated
Apr 23, 2026