Skin Conditioning

Arginine Aspartate

CAS 7675-83-4 EC 231-656-8
L-aspartic acid, compound with L-arginine (1:1)
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

L-aspartic acid, compound with L-arginine (1:1)

Purpose

Function

Skin Conditioning
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
MODERATE
US
Permitted
Absorptionlow
Sensitizationlow
MoSnot established
NOAEL3.131 mg/kg
ConcernLow
Verdict

Arginine (CAS 74-79-3) is one of the safest, most well-documented cosmetic amino acids. CIR-approved as safe across all product types including eye area and leave-on. FDA GRAS under 21 CFR 172.320, no EU concentration cap, no SCCS restrictions. Typical use range of 0.5-5% is well within the established safety envelope. Monitor pH when used as neutralizer — alkaline at higher concentrations.

US Note

GRAS as direct food additive under 21 CFR 172.320. No specific FDA restrictions on cosmetic use. 505 reported formulations in VCRP — highest among all alpha-amino acids at time of CIR review.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
7675-83-4
EC Number
231-656-8
Category
Skin Conditioning
Updated
Apr 23, 2026