antioxidant

Apigenin

INCI: APIGENIN
CAS 520-36-5 EC 208-292-3
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone

Purpose

Function

Antioxidant, Hair Conditioning, Anti-Inflammatory
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
GOOD
US
Permitted
Absorptionmoderate
Sensitizationlow
MoSnot established
NOAEL50 mg/kg
ConcernLow
Flags
endocrine_disruptor
Verdict

Apigenin is a naturally occurring flavone with demonstrated anti-inflammatory, barrier repair, and collagen synthesis properties, permitted in the EU without concentration restrictions, though human dermal absorption data under standardized conditions is lacking.

US Note

No GRAS classification. No specific FDA restrictions for cosmetic use.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
520-36-5
EC Number
208-292-3
INCI
APIGENIN
Category
antioxidant
Updated
Apr 2, 2026