Andrographolide
INCI: ANDROGRAPHOLIDE
CAS 5508-58-7 EC 226-852-5
3-[2-[Decahydro-6-Hydroxy-5-( Hydroxymethyl)-5,8a-Dimethyl-2-Methylenenaphthyl]Ethylidene]Dihydro-4-Hydroxyfuran-2(3H)-one
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
3-[2-[Decahydro-6-Hydroxy-5-( Hydroxymethyl)-5,8a-Dimethyl-2-Methylenenaphthyl]Ethylidene]Dihydro-4-Hydroxyfuran-2(3H)-one
Purpose
Function
skin conditioning, anti-inflammatory, antioxidant, antimicrobial
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
GOOD
US
Permitted
Absorptionmoderate
Sensitizationlow
MoSnot established
NOAEL666 mg/kg
ConcernLow
Flags
active_compoundanti_inflammatoryantioxidantskin_soothingnatural_diterpene
Verdict
Andrographolide is a plant-derived compound with anti-inflammatory and antioxidant properties, permitted for cosmetic use in both EU and US with good safety profile and low sensitization risk.
US Note
No specific FDA restrictions for topical use; used in anti-aging and soothing formulations
Assessment
Ratings
Reference