And)Dimethicone

One of the most extensively safety-tested cosmetic ingredients. CIR Final Amended Report (March 2022) covers 30 polymers and concludes safe as used except in airbrush delivery (insufficient data). FDA OTC-approved skin protectant at 1–30%. Creates occlusive but breathable barrier; does not disrupt stratum corneum lipid microstructure. Non-comedogenic per FDA classification. Medical-grade silicone for scar management regulated as FDA Class I device. Not PBT/vPvB — not subject to D4/D5/D6 EU restrictions. Avoid only in airbrush applications pending further safety data.

FDA OTC skin protectant active ingredient at 1–30% under Monograph M016 (21 CFR §347.10); CIR Final Amended Report March 2022 concludes safe for 30 methicone/dimethicone polymers as used