Allantoin(Skin Calming Agent)
Also known as Allantom
INCI: ALLANTOIN
CAS 97-59-6
Skin conditioner, keratolytic, anti-irritant, wound-healing agent; promotes orderly cell turnover; stimulates fibroblast proliferation; typical use 0.5–2%
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
Skin conditioner, keratolytic, anti-irritant, wound-healing agent; promotes orderly cell turnover; stimulates fibroblast proliferation; typical use 0.5–2%
Purpose
Function
Skin conditioner, keratolytic, anti-irritant, wound-healing agent; promotes orderly cell turnover; stimulates fibroblast proliferation; typical use 0.5–2%
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionhigh
Sensitizationnone
MoSadequate
NOAEL450 mg/kg
ConcernNone
Flags
cir-safe-as-used-2010us-otc-skin-protectant-21cfr347mos-21846dermal-absorption-5-20-pctnon-sensitizing-hript-n600comedogenicity-0cosmos-approvedreadily-biodegradableno-annex-listingcanada-symphytum-hotlist-riskeu_children_restrictedifra_fragrance
Verdict
CIR safe as used (2010). MoS approximately 21,846 (200x SCCS minimum). Non-sensitizing with HRIPT n=600+. Comedogenicity 0. US OTC dual status: 0.5-2% as skin protectant drug (21 CFR 347). DNEL 284 mg/kg/day (REACH). Ames negative. COSMOS approved nature-identical. Not listed in EU or global Annexes. Readily biodegradable.
US Note
OTC skin protectant active at 0.5-2.0% (21 CFR 347). Dual cosmetic/drug status. Wound healing claims = drug classification.
Assessment
Ratings
Reference