Active: Resveratrol
INCI: RESVERATROL
CAS 501-36-0
Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol
Purpose
Function
Antioxidant; AhR antagonist; Nrf2 activator; anti-inflammatory; anti-pollution active; SIRT1 activator; stilbene polyphenol
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionmoderate
Sensitizationnone
MoSadequate
NOAEL300 mg/kg
ConcernNone
Flags
anti-pollutionahr-antagonistnrf2-activatorsirt1-activatorpah-blockeranti-inflammatorylight-sensitiveencapsulation-recommendedstilbene-polyphenolanti-aging
Verdict
Resveratrol is a mechanistically validated anti-pollution active that antagonizes PAH-mediated AhR transcriptional activation while activating Nrf2 for cytoprotection and SIRT1 for anti-aging benefits; trans-resveratrol requires encapsulation or stabilized delivery systems due to light and oxygen sensitivity.
US Note
Permitted in cosmetics; no FDA restrictions; limited CIR assessment published; extensively studied in peer-reviewed literature; used at 0.1–1% in anti-aging and anti-pollution serums
Assessment
Ratings
Reference