Skin Conditioning

Acetylphytosphingosine

INCI: ACETYLPHYTOSPHINGOSINE
CAS 111599-76-5 (Tetraacetylphytosphingosine)
Acetylphytosphingosine is 1,3,4-Octadecanetriol, 2-amino-, acetate, (2S, 3S, 4R)
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Acetylphytosphingosine is 1,3,4-Octadecanetriol, 2-amino-, acetate, (2S, 3S, 4R)

Purpose

Function

Skin Conditioning, Hair Conditioning; ceramide precursor/sphingolipid derivative
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionlow
Sensitizationnone
MoSnot established
ConcernLow
Flags
natural-origin
Verdict

Must not be derived from bovine CNS tissue (21 CFR 700.27; EU TSE rules). Plant-derived sources such as yeast fermentation are standard. Part of CIR's comprehensive ceramide safety assessment.

US Note

Not restricted by FDA. CIR reviewed ceramides as a class and concluded safe in present practices of use and concentration

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
111599-76-5 (Tetraacetylphytosphingosine)
INCI
ACETYLPHYTOSPHINGOSINE
Category
Skin Conditioning
Updated
Apr 2, 2026