Acetylhexapeptide-8
Skin conditioning agent, humectant, neurotransmitter release inhibitor (SNAP-25 analog), anti-wrinkle
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
Skin conditioning agent, humectant, neurotransmitter release inhibitor (SNAP-25 analog), anti-wrinkle
Purpose
Function
Skin conditioning agent, humectant, neurotransmitter release inhibitor (SNAP-25 analog), anti-wrinkle
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
GOOD
US
Permitted
Absorptionlow
Sensitizationlow
MoSadequate
ConcernLow
Verdict
Cytotoxicity observed at ≥10 µM in vitro (IC50 = 34.9 µM HEK-293 cells); neurotransmitter inhibition at IC50 = 110 µM (5000× weaker than BoNT-A). Use concentration in cosmetics is orders of magnitude below concern thresholds. MW = 889 Da.
US Note
Permitted, not restricted under 21 CFR. CIR Expert Panel concluded safe at ≤0.005% in leave-on products.
Assessment
Ratings
Reference
Identifiers
No registry identifiers available for this ingredient.