Active Compound

Acetyl Tetrapeptide3

Anti-edema peptide for periorbital area. Mechanism: ACE inhibition — dose-dependent inhibition of angiotensin-converting enzyme reduces microvascular pressure; reduced vascular permeability — decreases endothelial cell permeability, inhibiting interstitial fluid leakage; anti-glycation — protects collagen and SOD from fructose-mediated glycation, preserving elasticity. Strengthens capillary walls, reduces dark circle appearance.
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Anti-edema peptide for periorbital area. Mechanism: ACE inhibition — dose-dependent inhibition of angiotensin-converting enzyme reduces microvascular pressure; reduced vascular permeability — decreases endothelial cell permeability, inhibiting interstitial fluid leakage; anti-glycation — protects collagen and SOD from fructose-mediated glycation, preserving elasticity. Strengthens capillary walls, reduces dark circle appearance.

Purpose

Function

Anti-edema peptide for periorbital area. Mechanism: ACE inhibition — dose-dependent inhibition of angiotensin-converting enzyme reduces microvascular pressure; reduced vascular permeability — decreases endothelial cell permeability, inhibiting interstitial fluid leakage; anti-glycation — protects collagen and SOD from fructose-mediated glycation, preserving elasticity. Strengthens capillary walls, reduces dark circle appearance.
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionnegligible
Sensitizationnone
MoSnot established
ConcernNone
Verdict

Acetyl Tetrapeptide-5 has triple-mechanism clinical substantiation for periorbital puffiness and dark circles: ACE inhibition, reduced vascular permeability, and anti-glycation, with in-vivo studies confirming in-vitro findings and no safety concerns.

US Note

No specific FDA restrictions. No pre-market approval required under MoCRA.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

Category
Active Compound
Updated
Apr 23, 2026

No registry identifiers available for this ingredient.