Acetyl Octapeptide-3 Sodium Polyaspartate
Description
Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue that targets the SNARE complex at the neuromuscular junction. Disrupts vesicle fusion with the neuronal membrane by competing for SNAP-25 binding sites, thereby inhibiting acetylcholine exocytosis and reducing muscle contraction at expression line sites.
Function
Properties
Regulatory Status
Acetyl Octapeptide-3 (SNAP-8) is a neurotransmitter-inhibiting peptide with presynaptic SNARE complex disruption mechanism. Clinically validated via hyaluronic acid microneedle patch delivery showing significant wrinkle reduction and improved skin elasticity. High molecular weight (1073.2 g/mol) severely limits passive topical penetration; advanced delivery systems (microneedles, nanoliposomes) required for efficacy. No EU or US regulatory restrictions.
No FDA or CIR restriction. No pre-market approval required under MoCRA for cosmetic peptides. CIR has not specifically reviewed Acetyl Octapeptide-3 as of this report.
Ratings
Identifiers
No registry identifiers available for this ingredient.