Acetyl Octapeptide-3
INCI: ACETYL OCTAPEPTIDE-3
CAS 868844-74-0
Acetyl Octapeptide-3 is the reaction product of acetic acid and Octapeptide-3
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
Acetyl Octapeptide-3 is the reaction product of acetic acid and Octapeptide-3
Purpose
Function
Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue that targets the SNARE complex at the neuromuscular junction. Disrupts vesicle fusion with the neuronal membrane by competing for SNAP-25 binding sites, thereby inhibiting acetylcholine exocytosis and reducing muscle contraction at expression line sites.
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
GOOD
US
Permitted
Absorptionlow
Sensitizationnone
MoSadequate
ConcernLow
Flags
neurotransmitter-inhibitorsnare-complexsnap-25-analoguesnap-8acetylcholine-inhibitor
Verdict
Acetyl Octapeptide-3 (SNAP-8) is a neurotransmitter-inhibiting peptide with presynaptic SNARE complex disruption mechanism. Clinically validated via hyaluronic acid microneedle patch delivery showing significant wrinkle reduction and improved skin elasticity. High molecular weight (1073.2 g/mol) severely limits passive topical penetration; advanced delivery systems (microneedles, nanoliposomes) required for efficacy. No EU or US regulatory restrictions.
US Note
No FDA or CIR restriction. No pre-market approval required under MoCRA for cosmetic peptides. CIR has not specifically reviewed Acetyl Octapeptide-3 as of this report.
Assessment
Ratings
Reference