conditioning-agent

Acetyl Methionine

INCI: ACETYL METHIONINE
CAS 65-82-7 EC 214-224-3 / 200-617-7
N-acetylmethionine
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

N-acetylmethionine

Purpose

Function

Skin conditioning; antioxidant
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
EXCELLENT
US
Permitted
Absorptionlow
Sensitizationnone
MoSadequate
NOAEL100 mg/kg
ConcernNone
Flags
cir-safefda-food-additivelow-ewg-hazardamino-acid-derivativeantioxidant-activity
Verdict

Acetyl Methionine is permitted in the EU as a skin conditioning agent with no Annex II/III restrictions. In the US, it is FDA-approved as a food additive with no cosmetic-specific restrictions. CIR assessment (2013) confirms safe use in cosmetics with low dermal absorption and non-sensitizing profile.

US Note

FDA-approved food additive under 21 CFR 172.372; no cosmetic-specific restrictions

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
65-82-7
EC Number
214-224-3 / 200-617-7
INCI
ACETYL METHIONINE
Category
conditioning-agent
Updated
Apr 2, 2026