Acetyl Hexapeptide-8 (1
Skin-conditioning agent; neuromodulating peptide
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
Skin-conditioning agent; neuromodulating peptide
Purpose
Function
Skin-conditioning agent; neuromodulating peptide
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Permitted
Safety
MODERATE
US
Permitted
Absorptionmoderate
Sensitizationlow
MoSadequate
ConcernModerate
Flags
peptideneuromodulatingocular-surface-concernblink-disruptionargirelineeye-area-caution
Verdict
Acetyl Hexapeptide-8 (Argireline) is a neurotransmitter-inhibiting peptide that competitively binds to SNAP-25 binding sites on the SNARE complex to inhibit acetylcholine exocytosis, with wrinkle depth reduction up to 30% at 10% concentration over 30 days and reported toxicity 4,000 times lower than botulinum toxin, though ocular surface impact via blink disruption has been documented.
US Note
Permitted as cosmetic ingredient; no concentration cap, but ocular surface concerns flagged in clinical literature
Assessment
Ratings
Reference
Identifiers
No registry identifiers available for this ingredient.