Skin Conditioning

Acetyl Hexapeptide-31

Acetyl Hexapeptide-31 is the product obtained by the acetylation of Hexapeptide-31.
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Acetyl Hexapeptide-31 is the product obtained by the acetylation of Hexapeptide-31.

Purpose

Function

Skin Conditioning, Hydrating (Aquaporin-3 booster — enhances water transport from basal epidermis to stratum corneum)
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
GOOD
US
Permitted
Absorptionlow
Sensitizationlow
MoSnot established
ConcernModerate
Verdict

Hexapeptide-3 is a fibronectin-mimetic peptide permitted in cosmetics; distinguish from Acetyl Hexapeptide-3 (Argireline). No CIR or SCCS review; molecular weight >500 Da supports low systemic absorption.

US Note

Permitted — not prohibited or restricted under 21 CFR

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

Category
Skin Conditioning
Updated
Apr 23, 2026

No registry identifiers available for this ingredient.