peptide

Acetyl Dipeptide-3 Aminohexanoate

INCI: ACETYL DIPEPTIDE-3 AMINOHEXANOATE
CAS 1265905-30-3
Acetyl Dipeptide-3 Aminohexanoate is the reaction product of acetic acid and Dipeptide-3 with 6-aminohexanoic acid
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details

Description

Acetyl Dipeptide-3 Aminohexanoate is the reaction product of acetic acid and Dipeptide-3 with 6-aminohexanoic acid

Purpose

Function

Skin conditioning agent, Antimicrobial defense stimulator
Profile

Properties

Silicone
Silicone free
Compliance

Regulatory Status

EU
Permitted
Safety
GOOD
US
Permitted
Absorptionlow
Sensitizationlow
MoSnot established
ConcernLow
Flags
no-sccs-opinionno-cir-reviewproprietary-peptidesupplier-data-onlycas-discrepancydata-gaplow-use-levelpeptideskin-conditioningantimicrobialheat-sensitive
Verdict

Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine, Lubrizol Life Science) is a proprietary synthetic peptide functioning as a skin conditioning agent via stimulation of human beta-defensins hBD-2 and hBD-3, supporting innate antimicrobial skin defense. Not listed in EU Annex II, III, IV, V, or VI — permitted under general provisions of Regulation (EC) 1223/2009. No SCCS opinion issued. No CIR review completed. No FDA restrictions; reported under MoCRA as a cosmetic ingredient. Very low use levels (0.005-0.05%) and peptide hydrolysis read-across are the primary safety arguments available. Formulators must request full toxicology package from supplier. Add below 40°C at final manufacturing stage.

US Note

No FDA monograph entry or specific restriction applies to Acetyl Dipeptide-3 Aminohexanoate. Not a sunscreen active. Under MoCRA, this ingredient would be disclosed in product listings with no special restrictions beyond general cosmetic GMP requirements. No CIR safety assessment has been completed for this specific ingredient. VCRP usage data not publicly confirmed for this peptide.

Assessment

Ratings

Comedogenic0/5
LowHigh
Irritancy0/5
LowHigh
Reference

Identifiers

CAS Number
1265905-30-3
INCI
ACETYL DIPEPTIDE-3 AMINOHEXANOATE
Category
peptide
Updated
Apr 2, 2026