2-Dimethylaminoethanol
pH Regulator, Buffering Agent
Limited Data
Insufficient safety data available. Consider enriching this ingredient.
Details
Description
pH Regulator, Buffering Agent
Purpose
Function
pH Regulator, Buffering Agent
Profile
Properties
Silicone
Silicone free
Compliance
Regulatory Status
EU
Restricted
Safety
MODERATE
US
Permitted
EU Max Concentration2.5%
Absorptionhigh
Sensitizationlow
MoSnot established
NOAEL7 mg/kg
ConcernModerate
Verdict
DMAE is an EU Annex III restricted substance (max 2.5% leave-on) due to its trialkylamine classification, with mandatory nitrosamine controls. Margin of safety calculations fall substantially below the SCCS threshold of 100 at the permitted limit, raising substantive safety concerns for leave-on applications.
US Note
No specific FDA monograph or restriction for cosmetic use. Under MoCRA, remains permissible without specific concentration limits; manufacturer bears responsibility for safety substantiation.
Assessment
Ratings
Reference
Identifiers
No registry identifiers available for this ingredient.